Endometriosis Knowledgebase


A repository for genes associated with endometriosis

Results


PMID 12934347
Gene Name BCL2
Condition Endometriosis
Association Associated
Population size 45
Population details 45 (16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal endometrum)
Sex Female
Associated genes Bcl-2, Bax
Other associated phenotypes Endometriosis, Adenomyosis
[Expression of Bcl-2 and Bax protein in endometriosis].

Hunan Yi Ke Da Xue Xue Bao. 2003 Apr;28(2):102-6.

Huang, Feng-ying| Lin, Qiu-hua| Fang, Xiao-ling

Department of Obstetrics and Gynecology, Second Xingya Hospital, Central South University, Changsha 410011, China.

OBJECTIVE: To study the pathophysiological effect of the expression of the apoptosis-regulating protein Bcl-2 and Bax in endometrosis. METHOD: Samples were obtained from 16 patients with adenomyosis, 12 ovarian endometriosis, and 17 normal endometrum. Bcl-2 and Bax expression were examined by immunohistochemical ABC staining with specific monoclonal antibodies. RESULTS: 1. The expression of Bcl-2 or Bax in the eutopic endometrium was the same as the normal endometrium and their immunoreactivity was found predominately in the glandular epithelial cells, showing obvious cyclic changes. 2. The Bcl-2 and Bax expression in adenomyosis was not the cyclic change in ectopic glandular cells. 3. Less expression of Bcl-2 and Bax was found in the ovarian endometriosis. CONCLUSIONS: 1. The Bcl-2 and Bax cyclic change may play an important role in the proliferation and physiologic death of normal and eutopic endometrial glandular epithelial cells. 2. Bcl-2 may play an important role in forming adenomyosis. 3. Bcl-2 may be the cause of forming chocolate cyst by prompting apoptosis.

Mesh Terms: Adult| Apoptosis| Endometriosis/genetics/*metabolism| Endometrium/metabolism| Female| Humans| Middle Aged| Ovarian Diseases/genetics/*metabolism| Proto-Oncogene Proteins/*biosynthesis/genetics| Proto-Oncogene Proteins c-bcl-2/*biosynthesis/geneti